Search | Engineering

Subscribe Submit

Home Journals Focus Achievement Fronts About Us 中文版

Resource Type

Journal Article 200

Conference Videos 3

Year

2024 1

2023 16

2022 24

2021 17

2020 17

2019 9

2018 15

2017 17

2016 9

2015 13

2014 9

2013 9

2012 5

2011 6

2010 12

2009 4

2008 6

2007 8

2002 1

2000 1

open ︾

Keywords

biomarker 15

molecular dynamics 9

molecular dynamics simulation 6

targeted therapy 4

China 3

Molecular dynamics simulation 3

cancer 3

molecular classification 3

molecular docking 3

molecular epidemiology 3

molecular markers 3

Alzheimer’s disease 2

Biomarker 2

Graphene 2

Synthesis 2

drug resistance 2

molecular 2

molecular dynamic 2

prognosis 2

open ︾

Search scope:

排序： Display mode:

Progress on molecular biomarkers and classification of malignant gliomas

Chuanbao Zhang, Zhaoshi Bao, Wei Zhang, Tao Jiang

Frontiers of Medicine 2013, Volume 7, Issue 2, Pages 150-156 doi: 10.1007/s11684-013-0267-1

Abstract: Great efforts have been made to incorporate new information about the molecular landscape of gliomas

Keywords： malignant glioma molecular biomarker IDH1 MGMT molecular classification

HTML PDF Collect

Human microbiome and prostate cancer development: current insights into the prevention and treatment

Solmaz Ohadian Moghadam, Seyed Ali Momeni

Frontiers of Medicine 2021, Volume 15, Issue 1, Pages 11-32 doi: 10.1007/s11684-019-0731-7

Abstract: The huge communities of microorganisms that symbiotically colonize humans are recognized as significant players in health and disease. The human microbiome may influence prostate cancer development. To date, several studies have focused on the effect of prostate infections as well as the composition of the human microbiome in relation to prostate cancer risk. Current studies suggest that the microbiota of men with prostate cancer significantly differs from that of healthy men, demonstrating that certain bacteria could be associated with cancer development as well as altered responses to treatment. In healthy individuals, the microbiome plays a crucial role in the maintenance of homeostasis of body metabolism. Dysbiosis may contribute to the emergence of health problems, including malignancy through affecting systemic immune responses and creating systemic inflammation, and changing serum hormone levels. In this review, we discuss recent data about how the microbes colonizing different parts of the human body including urinary tract, gastrointestinal tract, oral cavity, and skin might affect the risk of developing prostate cancer. Furthermore, we discuss strategies to target the microbiome for risk assessment, prevention, and treatment of prostate cancer.

Keywords： microbiome prostate cancer prevention treatment molecular pathological epidemiology (MPE) biomarker

HTML PDF Collect

Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis

Frontiers of Medicine 2022, Volume 16, Issue 2, Pages 216-226 doi: 10.1007/s11684-022-0920-7

Abstract: In summary, our study demonstrated that serum tsRNA signature may serve as a novel biomarker of HCC.

Keywords： tsRNA biomarker hepatocarcinoma

HTML PDF Collect

MiRNA-451 is a potential biomarker for estrogenicity in mouse uterus

Lingyan HOU, Yun LU, Ying LI, Li LI

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 1, Pages 99-105 doi: 10.1007/s11783-013-0490-7

Abstract: An alternative way is to evaluate estrogenicity through biomarker genes.MicroRNA (miRNA) is a class of regulatory gene, which has been shown to be a good biomarker for manystrong responses to E2 in the uterus of both immature and overiectomized mice, and could be a potential biomarker

Keywords： estrogen microRNA (miRNA) microarray biomarker

HTML PDF Collect

Plasma transthyretin is a nutritional biomarker in human morbidities

Frontiers of Medicine 2022, Volume 16, Issue 4, Pages 540-550 doi: 10.1007/s11684-022-0940-3

Abstract: Transthyretin (TTR) is a small liver-secreted plasma protein that shows close correlations with changes in lean body mass (LBM) during the entire human lifespan and agglomerates the bulk of nitrogen (N)-containing substrates, hence constituting the cornerstone of body building. Amino acids (AAs) dietary restriction causes inhibition of TTR production and impairs the accretion of LBM reserves. Inflammatory disorders result in cytokine-induced abrogation of TTR synthesis and urinary leakage of nitrogenous catabolites. Taken together, the data indicate that malnutrition and inflammation may similarly suppress the production of TTR through distinct and unrelated pathophysiological mechanisms while operating in concert to downsize LBM stores. The hepatic synthesis of TTR integrates both machineries, acting as a marker of reduced LBM resources still available for defense and repair processes. TTR operates as a universal surrogate analyte that allows for the grading of residual LBM capacity to reflect disease burden. Measurement of TTR is a simple, rapid, and inexpensive micro-method that may be reproduced on a daily basis, hence ideally suited for the follow-up of the most intricated clinical situations and as a reliable predictor of any morbidity outcome.

Keywords： lean body mass nutritional status transthyretin malnutrition inflammation amyloidosis

HTML PDF Collect

Biosensor-based assay of exosome biomarker for early diagnosis of cancer

Frontiers of Medicine 2022, Volume 16, Issue 2, Pages 157-175 doi: 10.1007/s11684-021-0884-z

Abstract: Exosome has recently become an attractive cancer biomarker in noninvasive early diagnosis because of

Keywords： biosensor exosome cancer diagnosis

HTML PDF Collect

Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1): a potential biomarker for the diagnosis

Changlin Cao, Jingxian Gu, Jingyao Zhang

Frontiers of Medicine 2017, Volume 11, Issue 2, Pages 169-177 doi: 10.1007/s11684-017-0505-z

Abstract: sTREM-1) is a special form of TREM-1 that can be directly tested in human body fluids and well-known biomarkerinfections (e.g., infection), and burn-related infections. sTREM-1 is a more sensitive and specific biomarkerTherefore, sTREM-1 is a feasible biomarker for the targeted therapy and rapid and early diagnosis of

Keywords： soluble triggering receptor expressed on myeloid cells-1 infectious diseases diagnosis and prognosis biomarker

HTML PDF Collect

Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker

Frontiers of Medicine 2022, Volume 16, Issue 5, Pages 723-735 doi: 10.1007/s11684-021-0905-y

Abstract: Therefore, CORO1A might be a potential biomarker and therapeutic target for ALS.

Keywords： amyotrophic lateral sclerosis coronin-1a autophagy pathogenesis

HTML PDF Collect

iTRAQ-based quantitative analysis of cancer-derived secretory proteome reveals TPM2 as a potential diagnostic biomarker

Yiming Ma,Ting Xiao,Quan Xu,Xinxin Shao,Hongying Wang

Frontiers of Medicine 2016, Volume 10, Issue 3, Pages 278-285 doi: 10.1007/s11684-016-0453-z

Abstract: In summary, this study revealed potential molecules for future biomarker applications and provided an

Keywords： iTRAQ secretome colorectal cancer TPM2

HTML PDF Collect

Sepsis biomarkers: an omics perspective

Xiao Liu, Hui Ren, Daizhi Peng

Frontiers of Medicine 2014, Volume 8, Issue 1, Pages 58-67 doi: 10.1007/s11684-014-0318-2

Abstract:

Sepsis is a common cause of death in hospitalized patients worldwide. The early detection of sepsis remains a great challenge for clinicians, and delayed diagnosis frequently undermines treatment efforts, thereby contributing to high mortality. Omics technologies allow high-throughput screening of sepsis biomarkers. This review describes currently available and novel sepsis biomarkers in the context of genomics, transcriptomics, proteomics, and metabolomics. The combination of these technologies can help refine the diagnosis of sepsis. This review paper serves as a reference for future studies that employ an integrated, multi-omics approach to disease identification.

Keywords： sepsis biomarker genomics transcriptomics proteomics metabolomics

HTML PDF Collect

Special issue on “Molecular Sensors and Molecular Logic Gates”

Luling Wu , Tony D. James

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1, Pages 1-3 doi: 10.1007/s11705-021-2134-y

HTML PDF Collect

Design of bio-oil additives via molecular signature descriptors using a multi-stage computer-aided molecular

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 2, Pages 168-182 doi: 10.1007/s11705-021-2056-8

Abstract: In this work, computer-aided molecular design tools were developed to design optimal solvents to upgradeAs different property prediction models consist different levels of structural information, molecularDue to the combinatorial nature of higher-order signatures, the complexity of a computer-aided molecular

Keywords： computer-aided molecular design bio-oil additives molecular signature descriptor

HTML PDF Collect

Molecular classification and molecular targeted therapy of cancer

Miao Xu, Jianyong Shao, Yixin Zeng

Frontiers of Medicine 2013, Volume 7, Issue 2, Pages 147-149 doi: 10.1007/s11684-013-0274-2

HTML PDF Collect

U-shaped microRNA expression pattern could be a new concept biomarker for environmental estrogen

Rui Duan, Yun Lu, Lingyan Hou, Lina Du, Lequn Sun, Xingfan Tang

Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 6, doi: 10.1007/s11783-016-0880-8

Abstract: estrogenic activity and that the typical nonmonotonic dose-response relationship could be used as a novel biomarker

Keywords： miRNA Prostate Estradiol Nonmonotonic dose-response Estrogenicity Drosha

HTML PDF Collect

study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein as a serum biomarker

Frontiers of Medicine 2022, Volume 16, Issue 3, Pages 378-388 doi: 10.1007/s11684-021-0840-y

Abstract: Macrolide and corticosteroid resistance has been reported in patients with Mycoplasma pneumoniae (MP) pneumonia (MPP). MP clearance is difficult to achieve through antibiotic treatment in sensitive patients with severe MPP (SMPP). SMPP in children might progress to airway remodeling and even bronchiolitis/bronchitis obliterans. Therefore, identifying serum biomarkers that indicate MPP progression and exploring new targeted drugs for SMPP treatment require urgency. In this study, serum samples were collected from patients with general MPP (GMPP) and SMPP to conduct proteomics profiling. The Fc fragment of the IgG-binding protein (FCGBP) was identified as the most promising indicator of SMPP. Biological enrichment analysis indicated uncontrolled inflammation in SMPP. ELISA results proved that the FCGBP level in patients with SMPP was substantially higher than that in patients with GMPP. Furthermore, the FCGBP levels showed a decreasing trend in patients with GMPP but the opposite trend in patients with SMPP during disease progression. Connectivity map analyses identified 25 possible targeted drugs for SMPP treatment. Among them, a mechanistic target of rapamycin kinase (mTOR) inhibitor, which is a macrolide compound and a cell proliferation inhibitor, was the most promising candidate for targeting SMPP. To our knowledge, this study was the first proteomics-based characterization of patients with SMPP and GMPP.

Keywords： severe Mycoplasma pneumoniae pneumonia children proteomics Fc fragment of the IgG-binding protein mechanistic target of rapamycin kinase inhibitor